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Association between PTGS1 polymorphisms and functional outcomes in Chinese patients with stroke during aspirin therapy: Interaction with smoking.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2017 May 15; Vol. 376, pp. 211-215. Date of Electronic Publication: 2017 Mar 14. - Publication Year :
- 2017
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Abstract
- Purpose: Prostaglandin-Endoperoxide Synthase 1 (PTGS1) and smoking may play important roles in aspirin nonresponsiveness, but the effect of their interaction on stroke outcomes remains largely unknown. We examined the effects of PTGS1 polymorphisms, smoking status, and their interaction on functional outcomes in a cohort of Chinese Han patients with stroke during aspirin therapy.<br />Methods: A total of 617 ischemic stroke patients taking aspirin were enrolled. Three single nucleotide polymorphisms (SNPs) rs1330344, rs3842788, and rs5788 in PTGS1 were determined for genotyping. Poor functional outcomes were defined as a modified Rankin Scale (mRS) of 3-6 at 90-day follow-up. The influence of PTGS1 gene-smoking interaction on functional outcomes was examined.<br />Results: Poor functional outcomes occurred in 145 (23.5%) patients. When adjusting multiple factors by logistic regression, CC genotype of rs1330344 was associated with poor functional outcomes (risk ratio [RR]=1.73; 95% confidence interval [CI]: 1.17-2.37). A similar connection was found in the CGC haplotype (RR=1.40; 95% CI: 1.08-1.77). Furthermore, we found a significant interaction between rs1330344 and smoking status (P <subscript>interaction</subscript> =0.018); the interaction effect between the PTGS1 haplotype and smoking also showed statistical significance (P <subscript>interaction</subscript> =0.040).<br />Conclusions: In Chinese Han stroke patients with aspirin therapy, the adverse effect of PTGS1 polymorphisms on functional outcomes may be modulated by the smoking status. PTGS1 gene-smoking interaction might in part reflect the heterogeneity in the prognosis of patients treated with aspirin.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Asian People genetics
Brain Ischemia complications
Brain Ischemia drug therapy
Brain Ischemia genetics
China
Female
Follow-Up Studies
Gene-Environment Interaction
Haplotypes
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Prospective Studies
Registries
Secondary Prevention
Stroke complications
Treatment Outcome
Aspirin therapeutic use
Cyclooxygenase 1 genetics
Fibrinolytic Agents therapeutic use
Smoking genetics
Stroke drug therapy
Stroke genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5883
- Volume :
- 376
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 28431615
- Full Text :
- https://doi.org/10.1016/j.jns.2017.03.014