pH Dependent synthesis of two isomeric dinuclear Cerium(II) complexes: Structures, DNA interactions, cytotoxic activity and apoptotic study.

Authors :: Gao EJ
Su JQ
Jin HT
Liu SJ
Zhao FC
Meng Y
Ma XY
Ge J
Sun YG
Zhang W
Zhu MC
Source :: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2017 May; Vol. 170, pp. 173-180. Date of Electronic Publication: 2017 Apr 11.
Publication Year :: 2017
Abstract: Two isomeric dinuclear Cerium(II) complexes 1 and 2, formulated as Ce <subscript>2</subscript> (phen) <subscript>2</subscript> (NO <subscript>3</subscript> ) <subscript>2</subscript> (L) <subscript>4</subscript> [L=phenylacetic acid, phen=1,10-phenanthroline] was synthesized under solvothermal conditions at different pH values. The two complexes were characterized by elemental analysis, IR and single crystal X-ray diffraction. Complexes 1 and 2 were studied the binding with DNA and against cytotoxic activity. Fluorescence analysis indicated that the two complexes can bind to DNA. The changes with different gradient concentration of DNA added into the complexes in absorption spectra show a strongπ-stacking interaction between the complexes and DNA base pairs. The Cerium(II) complexes showed good cytotoxic activity against cancer cell lines, being 2 the most potent complex. Apoptotic studies of the two novel dinuclear complexes showed significant inhibitory rate on cancer cell growth line KB.<br /> (Copyright © 2017. Published by Elsevier B.V.)

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