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Effects of high-fat diet and fructose-rich diet on obesity, dyslipidemia and hyperglycemia in the WBN/Kob-Lepr fa rat, a new model of type 2 diabetes mellitus.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2017 Jun 10; Vol. 79 (6), pp. 988-991. Date of Electronic Publication: 2017 Apr 21. - Publication Year :
- 2017
-
Abstract
- Obesity and type 2 diabetes mellitus (T2DM) are occurring at epidemic-like rates, and these epidemics appear to have emerged largely from changes in daily diet. In the present study, we compared effects of high-fat diet (HFD) and fructose-rich diet (FRD) in WBN/Kob-Lepr <superscript>fa</superscript> (WBKDF) rats that spontaneously develop obesity, dyslipidemia and T2DM. After a 4-week feeding of each diet, WBKDF-HFD and WBKDF-FRD rats exhibited aggravated obesity and dyslipidemia compared with WBKDF rats fed standard diet (STD). In contrast, hyperglycemia developed in WBKDF-STD rats was significantly inhibited in WBKDF-FRD rats, but not in WBKDF-HFD rats. The present study demonstrated that the 4-week feeding of HFD and FRD caused diet-induced obesity with a distinct phenotype in the glucose metabolism in WBKDF rats.
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 79
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 28442647
- Full Text :
- https://doi.org/10.1292/jvms.17-0136