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23Na nuclear magnetic resonance study of Na+-K+ pump inhibition by a fraction from uremic toxins.
- Source :
-
Clinical chemistry [Clin Chem] 1988 Oct; Vol. 34 (10), pp. 2044-7. - Publication Year :
- 1988
-
Abstract
- An in vitro inhibitor of Na+/K+-transporting ATPase (EC 3.6.1.37) was isolated from uremic plasma and normal urine by liquid chromatography. A 23Na nuclear magnetic resonance study involving living erythrocytes showed that this inhibitor causes impairment of the Na+-K+ pump of intact erythrocytes. This finding may explain the high intra-erythrocytic sodium concentration in those uremic patients exhibiting a high concentration of this inhibitor. The presence of this same inhibitor in normal urine suggests that it may play a physiological role.
Details
- Language :
- English
- ISSN :
- 0009-9147
- Volume :
- 34
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 2844439