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Genetic characterization of equid herpesvirus type 1 from cases of abortion in Poland.
- Source :
-
Archives of virology [Arch Virol] 2017 Aug; Vol. 162 (8), pp. 2329-2335. Date of Electronic Publication: 2017 Apr 27. - Publication Year :
- 2017
-
Abstract
- Equid herpesvirus type 1 (EHV-1) is a common viral infection associated with varied clinical outcomes including respiratory disease, abortion and neurological disease. We have characterized EHV-1 sequences (n = 38) obtained from cases of equine abortion in Poland between 1999 and 2016, based on sequencing of PCR products from open reading frames (ORF) 30 and 68 of the EHV-1 genome. The majority (81.6%) of sequences were not classified into any of the previously described groups based on the ORF68 sequence. The remaining sequences belonged to ORF68 group III (7.9%) or IV (10.5%). A haplotype network analysis did not show any obvious structure within networks of local Polish sequences, nor within a global network of 215 EHV-1 sequences when these networks were coloured based on the geographical origin of viruses or date of detection. Our data suggest that ORF68 does not provide a reliable molecular marker for epidemiological studies of EHV-1, at least in a global sense. Its usefulness to aid local investigations of individual outbreaks remains to be established. All but two Polish EHV-1 sequences belonged to the ORF30 N <subscript>752</subscript> genotype. The two ORF30 D <subscript>752</subscript> viruses were obtained from abortion cases in 2009 and 2010. Hence, abortion cases that occurred in Poland between 1999 and 2016 were caused predominantly by EHV-1 with the ORF30 N <subscript>752</subscript> genotype, with no indication of an increase in the prevalence of the ORF30 D <subscript>752</subscript> variant.
- Subjects :
- Abortion, Veterinary virology
Animals
Disease Outbreaks veterinary
Female
Genotype
Herpesviridae Infections virology
Horse Diseases virology
Open Reading Frames
Poland epidemiology
Polymerase Chain Reaction veterinary
Pregnancy
Sequence Analysis, DNA
Abortion, Veterinary epidemiology
Herpesviridae Infections veterinary
Herpesvirus 1, Equid genetics
Horse Diseases diagnosis
Horses virology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 162
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 28451902
- Full Text :
- https://doi.org/10.1007/s00705-017-3376-3