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Tau Oligomers in Sera of Patients with Alzheimer's Disease and Aged Controls.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2017; Vol. 58 (2), pp. 471-478. - Publication Year :
- 2017
-
Abstract
- Although tau protein was long regarded as an intracellular protein with several functions inside the cell, new evidence has shown tau secretion into the extracellular space. The active secretion of tau could be a physiological response of neurons to increased intracellular amounts of tau during the progression of tau pathology. We looked for potential differences in the serum levels of toxic tau oligomers in regards to cognitive impairment of subjects. We detected tau oligomers in the serum of Alzheimer's disease (AD) patients, but they were also present to some extent in the serum of healthy older subjects where the levels positively correlated with aging (Spearman r = 0.26, p = 0.016). On the contrary, we found lower levels of tau oligomers in the serum of mild cognitive impairment (MCI) (p = 0.033) and MCI-AD (p = 0.006) patients. These results could suggest that clearance of extracellular tau proteins takes place, in part, in the periphery. In the case of MCI patients, the lower levels of tau oligomers could be the result of impaired clearance of tau protein from interstitium to blood and consequent accumulation of tau aggregates in the brain.
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease complications
Amyloid beta-Peptides blood
Amyloid beta-Peptides cerebrospinal fluid
Cognitive Dysfunction blood
Cognitive Dysfunction etiology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Mental Status Schedule
Middle Aged
Peptide Fragments blood
tau Proteins cerebrospinal fluid
tau Proteins chemistry
Aging blood
Alzheimer Disease blood
tau Proteins blood
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 28453485
- Full Text :
- https://doi.org/10.3233/JAD-170048