Flex-nucleoside analogues - Novel therapeutics against filoviruses.

Authors :: Yates MK
Raje MR
Chatterjee P
Spiropoulou CF
Bavari S
Flint M
Soloveva V
Seley-Radtke KL
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 15; Vol. 27 (12), pp. 2800-2802. Date of Electronic Publication: 2017 Apr 22.
Publication Year :: 2017
Abstract: Fleximers, a novel type of flexible nucleoside that have garnered attention due to their unprecedented activity against human coronaviruses, have now exhibited highly promising levels of activity against filoviruses. The Flex-nucleoside was the most potent against recombinant Ebola virus in Huh7 cells with an EC <subscript>50</subscript> =2μM, while the McGuigan prodrug was most active against Sudan virus-infected HeLa cells with an EC <subscript>50</subscript> of 7μM.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)