Long non-codingRNA (lncRNA) TUG1 and the prognosis of cancer: a meta-analysis.

Authors :: Yu XH
Guo W
Zhang J
Ma C
Chu AJ
Wen BL
Zhang X
Yan XY
Wu CM
Wang DM
Qu YL
Source :: Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2017 Mar 31; Vol. 63 (3), pp. 36-39. Date of Electronic Publication: 2017 Mar 31.
Publication Year :: 2017
Abstract: Some studies assessed the association between lncRNA taurine-upregulated gene 1 (TUG1) and the survival in cancer. However, the results were inconclusive.  Therefore, we performed a meta-analysis to determine this association. We used the following electronic databases to search for eligible literature: PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. We used ORs and 95% CIs to measure the association between TUG1 and the survival of cancer. There was no significant association between TUG1 and OS of cancer (HR=1.26, 95% CI=0.97-1.64). In the subgroup analysis by cancer type, significant association could be find in osteosarcoma (HR=1.72, 95% CI=1.27-2.32) and digestive system's tumors (HR=1.66, 95% CI=1.04-2.66). In conclusion, this meta-analysis study indicated that TUG1 might associate with the OS of osteosarcoma and digestive system's tumors.