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Adducin in tumorigenesis and metastasis.

Authors :
Luo C
Shen J
Source :
Oncotarget [Oncotarget] 2017 Jul 18; Vol. 8 (29), pp. 48453-48459.
Publication Year :
2017

Abstract

Adducin is a membrane-skeletal protein localized at spectrin-actin junctions, involving in the formation of the network of cytoskeleton, cellular signal transduction, ionic transportation, cell motility and cell proliferation. While previous researches focused mainly on the relationship between adducin and hypertension, there are few studies focusing on the role of adducin in tumor. Previous studies showed that adducin played a role in the evolution and progression of neoplasm. This review makes a brief summary on the structure, function and mechanism of adducin and how adducin functions in tumorigenesis and metastasis.

Details

Language :
English
ISSN :
1949-2553
Volume :
8
Issue :
29
Database :
MEDLINE
Journal :
Oncotarget
Publication Type :
Academic Journal
Accession number :
28476036
Full Text :
https://doi.org/10.18632/oncotarget.17173