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Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts.
Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts.
- Source :
-
Fitoterapia [Fitoterapia] 2017 Jun; Vol. 119, pp. 168-174. Date of Electronic Publication: 2017 May 02. - Publication Year :
- 2017
-
Abstract
- Gymnosporia heterophylla (Celastraceae) is an African medicinal plants used to treat painful and inflammatory diseases with partial scientific validation. Solvent extractions followed by repeated chromatographic purification of the G. heterophylla aerial parts led to the isolation of one new β-dihydroagarofuran sesquiterpene alkaloid (1), and two triterpenes (2-3). In addition, eight known compounds including one β-dihydroagarofuran sesquiterpene alkaloid (4), and six triterpenes (5-10) were isolated. All structures were determined through extensive analysis of the NMR an MS data as well as by comparison with literature data. These compounds were evaluated for the anti-inflammatory activities against COX-1 and -2 inhibitory potentials. Most of the compound isolated showed non selective COX inhibitions except for 3-Acetoxy-1β-hydroxyLupe-20(29)-ene (5), Lup-20(29)-ene-1β,3β-diol (6) which showed COX-2 selective inhibition at 0.54 (1.85), and 0.45 (2.22) IC <subscript>50</subscript> , in mM (Selective Index), respectively. The results confirmed the presence of anti-inflammatory compounds in G. heterophylla which are important indicators for development of complementary medicine for inflammatory reactions; however, few could be useful as selective COX-2 inhibitor.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Alkaloids isolation & purification
Cyclooxygenase Inhibitors isolation & purification
Molecular Structure
Plant Components, Aerial chemistry
Plant Extracts chemistry
Plants, Medicinal chemistry
Sesquiterpenes isolation & purification
Triterpenes isolation & purification
Alkaloids chemistry
Celastraceae chemistry
Cyclooxygenase Inhibitors chemistry
Sesquiterpenes chemistry
Triterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 119
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 28476411
- Full Text :
- https://doi.org/10.1016/j.fitote.2017.04.015