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[Diabetogenic properties of Coxsackie A13 and Coxsackie B4 viruses in experimental infection in mice].
- Source :
-
Voprosy virusologii [Vopr Virusol] 1988 Jul-Aug; Vol. 33 (4), pp. 469-74. - Publication Year :
- 1988
-
Abstract
- Studies of diabetogenic properties of Coxsackie A13 and B4 viruses in mice sensitive to diabetes (males, DBA line) and resistant (males and females F1(CBA X C57BL/6), females DBA/2 using in the latter case the subdiabetogenic doses of alloxan revealed in the infected animals biochemical changes manifested by reduction of glucose tolerance and disorders in the synthesis of immunoreactive insulin. Most marked changes were observed in males of DBA/2 line infected with Coxsackie B4 virus and in males F1 (CBA X C57BL/6) and females DBA/2 infected with Coxsackie A14 virus. With Coxsackie A13 virus such data have been obtained for the first time.
- Subjects :
- Animals
Antigens, Viral analysis
Blood Glucose analysis
Coxsackievirus Infections blood
Coxsackievirus Infections immunology
Diabetes Mellitus, Experimental blood
Diabetes Mellitus, Experimental immunology
Disease Susceptibility
Enterovirus immunology
Enterovirus B, Human immunology
Female
Insulin Antibodies analysis
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
Myocardium immunology
Pancreas immunology
Time Factors
Coxsackievirus Infections complications
Diabetes Mellitus, Experimental etiology
Enterovirus pathogenicity
Enterovirus B, Human pathogenicity
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-4088
- Volume :
- 33
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Voprosy virusologii
- Publication Type :
- Academic Journal
- Accession number :
- 2848368