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Nickel catalyzed enantioselective hydroarsination of nitrostyrene.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Jun 08; Vol. 53 (47), pp. 6307-6310. - Publication Year :
- 2017
-
Abstract
- A catalytic asymmetric hydroarsination reaction of an activated alkene viz. (E)-nitrostyrene was developed using chiral PCP Pt-, Pd- and Ni-pincer complexes as catalysts. The corresponding chiral tertiary arsine adduct was obtained in ees of up to 80% under mild reaction conditions using the PCP Ni-Cl pincer catalyst. The arsine adduct was furnished with catalyst loadings of 1-5 mol% and the reaction duration ranging from <5 min to 180 min. The subsequent coordination of the hydroarsination product to gold(i) chloride allowed for the confirmation of the stereochemistry of the arsine adduct via crystallographic analysis.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 53
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 28492693
- Full Text :
- https://doi.org/10.1039/c7cc02044a