Standardization of the apparent diffusion coefficient value of bladder cancer across different centers: Applicability in predicting aggressive pathologic phenotypes.

Authors :: Nishizawa T
Yoshida S
Koga F
Tanaka H
Kaga M
Watanabe K
Fukushima H
Nakanishi Y
Yokoyama M
Ishioka J
Matsuoka Y
Saito K
Fujii Y
Kihara K
Source :: Clinical imaging [Clin Imaging] 2017 Jul - Aug; Vol. 44, pp. 121-126. Date of Electronic Publication: 2017 May 05.
Publication Year :: 2017
Abstract: Purpose: We investigated whether the standardized apparent diffusion coefficient (ADC) value reflects bladder cancer characteristics across different centers.<br />Methods: Ninety-eight bladder cancer patients underwent MRI at two institutions. Standardized tumor ADC (sT-ADC) was calculated by dividing absolute tumor ADC (aT-ADC) by that of gluteus maximus. We compared ADCs between MRI protocols according to grade and T-stage.<br />Results: The differences in aT-ADC between MRI protocols were negated by sT-ADC. The best sT-ADC cut-offs to predict cancer aggressiveness in the development cohort worked in the validation cohort compared to the development cohort.<br />Conclusion: Standardized ADC overcomes the incompatibility between different MRI protocols.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)

Subjects :: Adult
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Magnetic Resonance Imaging methods
Male
Middle Aged
Phenotype
Reference Standards
Urinary Bladder diagnostic imaging
Urinary Bladder Neoplasms diagnostic imaging
Diffusion Magnetic Resonance Imaging methods
Urinary Bladder pathology
Urinary Bladder Neoplasms pathology

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