Back to Search Start Over

Beta-adrenergic stimulation prior to darkness advances the nocturnal increase of Syrian hamster pineal melatonin synthesis.

Authors :
Gonzalez-Brito A
Reiter RJ
Santana C
Menendez-Pelaez A
Guerrero JM
Source :
Brain research [Brain Res] 1988 Dec 20; Vol. 475 (2), pp. 393-6.
Publication Year :
1988

Abstract

Pineal glands of male Syrian hamsters stimulated in vivo with isoproterenol (ISO) for 4 h before the onset of darkness showed a 4-h advance in the timing of the nighttime increases in both N-acetyltransferase activity and melatonin levels. When ISO (1 mg/kg) was administered every 2 h to animals kept in light during the night, a significant increase in melatonin synthesis was observed after 4-6 h. The results suggest that the Syrian hamster pineal gland can respond in vivo to continuous beta-adrenergic stimulation, but a lag period of 4-6 h is required before there is an increase in melatonin synthesis.

Details

Language :
English
ISSN :
0006-8993
Volume :
475
Issue :
2
Database :
MEDLINE
Journal :
Brain research
Publication Type :
Academic Journal
Accession number :
2850840
Full Text :
https://doi.org/10.1016/0006-8993(88)90633-6