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Impact of risk-reducing salpingo-oophorectomy in premenopausal women.

Authors :
Vermeulen RFM
Beurden MV
Korse CM
Kenter GG
Source :
Climacteric : the journal of the International Menopause Society [Climacteric] 2017 Jun; Vol. 20 (3), pp. 212-221. Date of Electronic Publication: 2017 Mar 02.
Publication Year :
2017

Abstract

Objectives: To describe implications of premenopausal risk-reducing salpingo-oophorectomy (RRSO) on quality of life, endocrine symptoms, sexual function, osteoporosis, cardiovascular health, metabolic syndrome, cognitive impairment and safety of hormone replacement therapy.<br />Methods: We searched the following electronic databases: The Cochrane Library, EMBASE, PsycInfo, and MEDLINE. We selected controlled and uncontrolled trials of premenopausal women undergoing RRSO. Two authors independently assessed studies for inclusion. Reference lists of included reports were searched manually for additional studies.<br />Results: Surgical menopause leads to more menopausal complaints and sexual dysfunction than natural menopause. Overall quality of life is not affected by surgery. In the limited literature, there is no evidence that RRSO leads to more osteopenia in comparison with natural menopause at a young age. Cohort studies show a slight impaired cardiovascular health. Cognitive function decreases later in life in premenopausal oophorectomized women. Short-term hormone replacement therapy seems to decline postmenopausal complaints and does not seem to increase the risk for breast carcinoma in mutation carriers without a personal history of breast carcinoma.<br />Conclusions: The conclusions of this systematic review are limited by the absence of randomized, controlled trials. There is growing evidence from observational studies that RRSO may impact negatively on all-cause non-survival endpoints.

Details

Language :
English
ISSN :
1473-0804
Volume :
20
Issue :
3
Database :
MEDLINE
Journal :
Climacteric : the journal of the International Menopause Society
Publication Type :
Academic Journal
Accession number :
28509627
Full Text :
https://doi.org/10.1080/13697137.2017.1285879