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A Map of Anticipatory Activity in Mouse Motor Cortex.
- Source :
-
Neuron [Neuron] 2017 May 17; Vol. 94 (4), pp. 866-879.e4. - Publication Year :
- 2017
-
Abstract
- Activity in the mouse anterior lateral motor cortex (ALM) instructs directional movements, often seconds before movement initiation. It is unknown whether this preparatory activity is localized to ALM or widely distributed within motor cortex. Here we imaged activity across motor cortex while mice performed a whisker-based object localization task with a delayed, directional licking response. During tactile sensation and the delay epoch, object location was represented in motor cortex areas that are medial and posterior relative to ALM, including vibrissal motor cortex. Preparatory activity appeared first in deep layers of ALM, seconds before the behavioral response, and remained localized to ALM until the behavioral response. Later, widely distributed neurons represented the outcome of the trial. Cortical area was more predictive of neuronal selectivity than laminar location or axonal projection target. Motor cortex therefore represents sensory, motor, and outcome information in a spatially organized manner.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Axons
Calcium metabolism
Decision Making
Image Processing, Computer-Assisted
Mice
Motor Cortex metabolism
Optical Imaging
Pyramidal Tracts metabolism
Pyramidal Tracts physiology
Vibrissae
Behavior, Animal physiology
Motor Activity physiology
Motor Cortex physiology
Neurons physiology
Touch physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 94
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 28521137
- Full Text :
- https://doi.org/10.1016/j.neuron.2017.05.005