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mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.

Authors :
Burke LK
Darwish T
Cavanaugh AR
Virtue S
Roth E
Morro J
Liu SM
Xia J
Dalley JW
Burling K
Chua S
Vidal-Puig T
Schwartz GJ
Blouet C
Source :
ELife [Elife] 2017 May 23; Vol. 6. Date of Electronic Publication: 2017 May 23.
Publication Year :
2017

Abstract

Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.

Details

Language :
English
ISSN :
2050-084X
Volume :
6
Database :
MEDLINE
Journal :
ELife
Publication Type :
Academic Journal
Accession number :
28532548
Full Text :
https://doi.org/10.7554/eLife.22848