Analysis of Anelloviridae sequences characterized from serial human and animal biological samples.

Authors :: Bédarida S
Dussol B
Signoli M
Biagini P
Source :: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2017 Sep; Vol. 53, pp. 89-93. Date of Electronic Publication: 2017 May 20.
Publication Year :: 2017
Abstract: Rolling-circle amplification-sequence-independent single primer amplifications (RCA-SISPA) and/or RCA-PCR-based approaches were applied to serial human plasma and animal (domestic cat) saliva samples. Complete SENV-H-related and PRA4 Anelloviridae genomes were characterized and analysed over time (~16 and 6.5years for human and animal samples, respectively). Genomic sequences and deduced putative coding regions were compared. Comparable values, i.e. ~2×10 <superscript>-4</superscript> subs/site/year, were obtained for estimated rates of non-synonymous substitutions. A "hot-spot" of mutations located on the SENV-H-related ORF1 was identified. These results are first data concerning Anelloviridae evolution in a human and an animal host based on the analysis of complete sequences.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Language :: English
ISSN :: 1567-7257
Volume :: 53
Database :: MEDLINE
Journal :: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Publication Type :: Academic Journal
Accession number :: 28536071
Full Text :: https://doi.org/10.1016/j.meegid.2017.05.017

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