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Association of Protein Intake with Bone Mineral Density and Bone Mineral Content among Elderly Women: The OSTPRE Fracture Prevention Study.
Association of Protein Intake with Bone Mineral Density and Bone Mineral Content among Elderly Women: The OSTPRE Fracture Prevention Study.
- Source :
-
The journal of nutrition, health & aging [J Nutr Health Aging] 2017; Vol. 21 (6), pp. 622-630. - Publication Year :
- 2017
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Abstract
- It has been hypothesized that high protein intakes are associated with lower bone mineral content (BMC). Previous studies yield conflicting results and thus far no studies have undertaken the interaction of body mass index (BMI) and physical activity with protein intakes in relation to BMC and bone mineral density (BMD).<br />Objective: To evaluate the associations of dietary total protein (TP), animal protein (AP) and plant protein (PP) intakes with BMC and BMD and their changes. We tested also the interactions of protein intake with, obesity (BMI ≤30 vs. >30 kg/m2) and physical activity level (passive vs. active). Design/ Setting: Prospective cohort study (Osteoporosis Risk-Factor and Fracture-Prevention Study). Participants/measures: At the baseline, 554 women aged 65-72 years filled out a 3-day food record and a questionnaire covering data on lifestyle, physical activity, diseases, and medications. Intervention group received calcium 1000 mg/d and cholecalciferol 800 IU for 3 years. Control group received neither supplementation nor placebo. Bone density was measured at baseline and year 3, using dual energy x-ray absorptiometry. Multivariable regression analyses were conducted to examine the associations between protein intake and BMD and BMC.<br />Results: In cross-sectional analyses energy-adjusted TP (P≤0·029) and AP (P≤0·045) but not PP (g/d) were negatively associated with femoral neck (FN) BMD and BMC. Women with TP≥1·2 g/kg/body weight (BW) (Ptrend≤0·009) had lower FN, lumbar spine (LS) and total BMD and BMC. In follow-up analysis, TP (g/kg/BW) was inversely associated with LS BMD and LS BMC. The detrimental associations were stronger in women with BMI<30 kg/m2. In active women, TP (g/kg/BW) was positively associated with LS BMD and FN BMC changes.<br />Conclusions: This study suggests detrimental associations between protein intake and bone health. However, these negative associations maybe counteracted by BMI>30 kg/m2 and physical activity.<br />Competing Interests: The authors have no relevant interests to declare
- Subjects :
- Absorptiometry, Photon methods
Aged
Aged, 80 and over
Animals
Bone and Bones metabolism
Calcium, Dietary pharmacology
Cholecalciferol pharmacology
Cross-Sectional Studies
Dietary Proteins administration & dosage
Dietary Proteins pharmacology
Dietary Supplements
Energy Intake
Female
Fractures, Bone etiology
Fractures, Bone metabolism
Fractures, Bone prevention & control
Humans
Osteoporosis, Postmenopausal metabolism
Osteoporosis, Postmenopausal prevention & control
Prospective Studies
Regression Analysis
Surveys and Questionnaires
Body Mass Index
Bone Density drug effects
Bone and Bones drug effects
Diet
Dietary Proteins adverse effects
Exercise
Osteoporosis, Postmenopausal etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1760-4788
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The journal of nutrition, health & aging
- Publication Type :
- Academic Journal
- Accession number :
- 28537325
- Full Text :
- https://doi.org/10.1007/s12603-016-0800-4