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Immunohistochemical evaluation of epidermal proliferation, differentiation and melanocytic density in symmetrical acrokeratoderma.
- Source :
-
Clinical and experimental dermatology [Clin Exp Dermatol] 2017 Jul; Vol. 42 (5), pp. 509-515. Date of Electronic Publication: 2017 May 22. - Publication Year :
- 2017
-
Abstract
- Background: Symmetrical acrokeratoderma (SAK) is characterized by brown to black hyperkeratotic patches on acral regions. Although epidermal hyperkeratosis and acanthosis are consistent pathological changes, the nature of epidermal hyperplasia is unknown.<br />Aim: To evaluate epidermal proliferation and differentiation and melanocytic density in skin lesions of SAK.<br />Methods: Expression of keratin 10 (K10), K14, K16, involucrin, filaggrin, Ki-67, and Melan-A was detected by immunohistochemistry in eight patients with SAK, seven patients with ichthyosis vulgaris (IV) and six healthy controls (HCs).<br />Results: Expression of K14, K16, involucrin and filaggrin was upregulated in patients with SAK compared with patients with IV and the HCs (P < 0.01-0.05), but K10 expression was similar for the three groups (P > 0.05). Numbers of Ki-67+ and Melan-A+ cells were higher in patients with SAK than in patients with IV and the HCs (P < 0.05).<br />Conclusions: These results demonstrate that excessive keratinocyte proliferation and abnormal differentiation contribute to epidermal hyperplasia, while melanocytic proliferation is responsible for the pigmented lesions in SAK.<br /> (© 2017 British Association of Dermatologists.)
- Subjects :
- Adolescent
Adult
Epidermis metabolism
Female
Filaggrin Proteins
Humans
Immunohistochemistry
Intermediate Filament Proteins metabolism
Keratinocytes metabolism
Keratosis metabolism
Ki-67 Antigen metabolism
Male
Protein Precursors metabolism
Skin metabolism
Skin pathology
Up-Regulation
Young Adult
Cell Differentiation
Cell Proliferation
Epidermal Cells
Keratinocytes cytology
Keratins metabolism
Keratosis pathology
Melanocytes cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2230
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical and experimental dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 28543665
- Full Text :
- https://doi.org/10.1111/ced.13118