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Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography.

Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography.

Authors :
Örkényi R
Éles J
Faigl F
Vincze P
Prechl A
Szakács Z
Kóti J
Greiner I
Source :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jul 17; Vol. 56 (30), pp. 8742-8745. Date of Electronic Publication: 2017 Jun 19.
Publication Year :
2017

Abstract

Continuous-flow multistep synthesis is combined with quasi-continuous final-product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desired monosubstituted product can be continuously separated from the co- and by-products in a purity of over 99 % by coupling a flow reactor sequence to a multiple dual-mode (MDM) centrifugal partition chromatography (CPC) device. This purification technique has many advantages over HPLC, such as higher resolution and no need for column replacement or silica recycling, and it does not suffer from irreversible adsorption.<br /> (© 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)

Details

Language :
English
ISSN :
1521-3773
Volume :
56
Issue :
30
Database :
MEDLINE
Journal :
Angewandte Chemie (International ed. in English)
Publication Type :
Academic Journal
Accession number :
28548374
Full Text :
https://doi.org/10.1002/anie.201703852