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Neuropeptides: A promising target for treating seizures.

Authors :
Menon N
Prabhavalkar KS
Bhatt LK
Source :
Neuropeptides [Neuropeptides] 2017 Oct; Vol. 65, pp. 63-70. Date of Electronic Publication: 2017 May 24.
Publication Year :
2017

Abstract

Seizures are serious neurological disorders affecting nearly 50 million people worldwide. Seizures are characterized by abnormal, repetitive and synchronised firing of the neurons which is produced as a result of imbalance in the levels of the excitatory and inhibitory neurotransmitters. Neuropeptides are found to regulate seizures by rectifying this imbalance. These neuropeptides are stored in the dense core synaptic vesicles, and are released on excitation. This review focuses on certain neuropeptides which can alleviate both, the effects of seizures as well as epileptogenesis. Thus making it an attractive target for the management of seizures.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1532-2785
Volume :
65
Database :
MEDLINE
Journal :
Neuropeptides
Publication Type :
Academic Journal
Accession number :
28559061
Full Text :
https://doi.org/10.1016/j.npep.2017.05.001