Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development.

Authors :: Zyuz'kov GN
Suslov NI
Povet'eva TN
Nesterova YV
Afanas'eva OG
Udut EV
Miroshnichenko LA
Simanina EV
Polyakova TY
Stavrova LA
Chaikovskii AV
Kul'pin PV
Udut VV
Dygai AM
Zhdanov VV
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 May; Vol. 163 (1), pp. 18-21. Date of Electronic Publication: 2017 Jun 05.
Publication Year :: 2017
Abstract: Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.

Subjects :: Animals
Anthracenes pharmacology
Anthracenes therapeutic use
Brain drug effects
Brain metabolism
Brain Diseases psychology
Exploratory Behavior drug effects
Male
Mice
Neural Stem Cells drug effects
Regenerative Medicine
Brain Diseases drug therapy
JNK Mitogen-Activated Protein Kinases antagonists & inhibitors
JNK Mitogen-Activated Protein Kinases metabolism

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