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Effects of phenobarbitone and 6-methylprednisolone pretreatment on pressure/flow relations in the superior mesenteric and iliac arterial beds of the rat.
- Source :
-
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 1985 Mar; Vol. 37 (3), pp. 164-9. - Publication Year :
- 1985
-
Abstract
- The in-situ blood perfused rat superior mesenteric arterial and right iliac arterial preparations were used to investigate the effects of pretreatment for 5 days with either phenobarbitone (80 mg kg-1 daily) or 6-methylprednisolone (17 mg kg-1 daily) on regional vascular resistances. The elevation of the regression of perfusion pressure on perfusion rate in the superior mesenteric arterial bed was significantly decreased by both phenobarbitone and 6-methylprednisolone over the range of flow rates used. Neither phenobarbitone nor 6-methylprednisolone had a significant effect on hepatic portal venous pressure nor was there any significant effect on the regression of perfusion pressure on flow rate in the in-situ iliac arterial bed. It is concluded that pretreatment with either phenobarbitone or 6-methylprednisolone lowers vascular resistance in the superior mesenteric arterial by approximately 9 and 8% respectively but does not affect vascular resistance in the iliac arterial bed.
- Subjects :
- Animals
Iliac Artery physiology
In Vitro Techniques
Liver drug effects
Liver Circulation drug effects
Male
Organ Size drug effects
Perfusion
Rats
Rats, Inbred Strains
Splanchnic Circulation drug effects
Blood Pressure drug effects
Methylprednisolone pharmacology
Phenobarbital pharmacology
Regional Blood Flow drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3573
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of pharmacy and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2858562
- Full Text :
- https://doi.org/10.1111/j.2042-7158.1985.tb05033.x