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Relationship between expression of PD-L1 and tumor angiogenesis, proliferation, and invasion in glioma.
- Source :
-
Oncotarget [Oncotarget] 2017 Jul 25; Vol. 8 (30), pp. 49702-49712. - Publication Year :
- 2017
-
Abstract
- Programmed death ligand 1 (PD-L1) is highly expressed in many cancers. We investigated the expression of PD-L1 and its relationship with vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 and KI-67 expression in 64 patients with primary glioma. The expression rate of PD-L1 in glioma patients was 78.12%. PD-L1 levels correlated with the tumor grade (p = 0.013), VEGF status (p = 0.002) and KI-67 status (p = 0.002). In addition, PD-L1 levels correlated positively with VEGF (r = 0.314, p = 0.011) and KI-67 (r = 0.391, p = 0.001) levels when the data were treated as continuous variables. This is the first report suggesting that PD-L1 is important for glioma angiogenesis and proliferation. Thus, further research should be conducted to assess the combination of targeted VEGF therapy and anti-PD-L1 immunotherapy for the treatment of glioma.
- Subjects :
- Adult
Aged
Cell Line, Tumor
Cell Movement
Cell Proliferation
Female
Humans
Ki-67 Antigen genetics
Ki-67 Antigen metabolism
Male
Matrix Metalloproteinase 9 genetics
Matrix Metalloproteinase 9 metabolism
Middle Aged
Neoplasm Grading
Neoplasm Staging
Vascular Endothelial Growth Factor A genetics
Vascular Endothelial Growth Factor A metabolism
B7-H1 Antigen genetics
Biomarkers, Tumor
Gene Expression
Glioma genetics
Glioma pathology
Neovascularization, Pathologic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 8
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 28591697
- Full Text :
- https://doi.org/10.18632/oncotarget.17922