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Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
- Source :
-
Nature communications [Nat Commun] 2017 Jun 09; Vol. 8, pp. 15724. Date of Electronic Publication: 2017 Jun 09. - Publication Year :
- 2017
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Abstract
- Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10 <superscript>-10</superscript> ), 3p22.1 (rs67311347, P=2.5 × 10 <superscript>-8</superscript> ), 3q26.2 (rs10936602, P=8.8 × 10 <superscript>-9</superscript> ), 8p21.3 (rs2241261, P=5.8 × 10 <superscript>-9</superscript> ), 10q24.33-q25.1 (rs11813268, P=3.9 × 10 <superscript>-8</superscript> ), 11q22.3 (rs74911261, P=2.1 × 10 <superscript>-10</superscript> ) and 14q24.2 (rs4903064, P=2.2 × 10 <superscript>-24</superscript> ). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 28598434
- Full Text :
- https://doi.org/10.1038/ncomms15724