KFLC Index utility in multiple sclerosis diagnosis: Further confirmation.

Authors :: Pieri M
Storto M
Pignalosa S
Zenobi R
Buttari F
Bernardini S
Centonze D
Dessi M
Source :: Journal of neuroimmunology [J Neuroimmunol] 2017 Aug 15; Vol. 309, pp. 31-33. Date of Electronic Publication: 2017 May 12.
Publication Year :: 2017
Abstract: The Multiple Sclerosis (MS) diagnosis is based on dissemination of focal lesions in time and space. The free light chains (FLCs) determination might be a sensitive alternative to oligoclonal bands assay. The study aim was to redefine sensitivity, specificity of the kFLC Index cut-off. We analyzed serum and cerebrospinal fluid of 176 patients, with different neurological disorders. We obtained a cut off of 12,3 for kFLC Index with a sensitivity and specificity of 93% and 100% respectively. Our data confirm that the kFLC Index is a valid tool in the diagnosis of MS.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)