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Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2017 Sep; Vol. 53, pp. 206-211. Date of Electronic Publication: 2017 Jun 08. - Publication Year :
- 2017
-
Abstract
- Rotavirus is one of the leading causes of acute gastroenteritis in infants and young children. RVAs infect not only humans but also a wide range of mammals including rats, which represent a reservoir of several other zoonotic pathogens. Due to the segmented nature of the RVA genome, animal RVA strains can easily adapt to the human host by reassortment with co-infecting human viruses. This study aims to detect and characterize RVA in the intestinal content of Italian sinantropic rats (Rattus rattus). Out of 40 samples examined following molecular approach, one resulted positive for RVA. The molecular characterization of VP1-4, 6 and 7, and NSP1-5 genes by sequencing revealed the genomic constellation G3-P[3]-I1-R11-C11-M10-A22-N18-T14-E18-H13. This uncommon genomic combination includes: the VP1-4,VP7, the NSP1, 3, 4 and 5 gene segments, closely related to those of RVA from rodents, the N18 novel genotype established for the NSP2 gene segment and the human Wa-like VP6 gene, suggesting interspecies reassortment.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Disease Reservoirs virology
Farms
Genotype
Humans
Italy
Molecular Typing
Protein Isoforms genetics
Rats
Reassortant Viruses classification
Reassortant Viruses isolation & purification
Rotavirus classification
Rotavirus isolation & purification
Rotavirus Infections virology
Genome, Viral
Phylogeny
RNA, Viral genetics
Reassortant Viruses genetics
Rotavirus genetics
Rotavirus Infections veterinary
Viral Core Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 53
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28603021
- Full Text :
- https://doi.org/10.1016/j.meegid.2017.06.008