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Comparison of Two Phenotypic Algorithms To Detect Carbapenemase-Producing Enterobacteriaceae.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Jul 25; Vol. 61 (8). Date of Electronic Publication: 2017 Jul 25 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- A novel algorithm designed for the screening of carbapenemase-producing Enterobacteriaceae (CPE), based on faropenem and temocillin disks, was compared to that of the Committee of the Antibiogram of the French Society of Microbiology (CA-SFM), which is based on ticarcillin-clavulanate, imipenem, and temocillin disks. The two algorithms presented comparable negative predictive values (98.6% versus 97.5%) for CPE screening among carbapenem-nonsusceptible Enterobacteriaceae However, since 46.2% ( n = 49) of the CPE were correctly identified as OXA-48-like producers by the faropenem/temocillin-based algorithm, it significantly decreased the number of complementary tests needed (42.2% versus 62.6% with the CA-SFM algorithm).<br /> (Copyright © 2017 American Society for Microbiology.)
- Subjects :
- Carbapenem-Resistant Enterobacteriaceae drug effects
Carbapenem-Resistant Enterobacteriaceae metabolism
Clavulanic Acids pharmacology
Enterobacteriaceae Infections drug therapy
Enterobacteriaceae Infections microbiology
Humans
Ticarcillin pharmacology
Algorithms
Anti-Bacterial Agents pharmacology
Bacterial Proteins metabolism
Carbapenem-Resistant Enterobacteriaceae enzymology
Disk Diffusion Antimicrobial Tests methods
Imipenem pharmacology
Penicillins pharmacology
beta-Lactamases metabolism
beta-Lactams pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 61
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 28607010
- Full Text :
- https://doi.org/10.1128/AAC.00796-17