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A 1 H-NMR based metabolomics study of the intervention effect of mangiferin on hyperlipidemia hamsters induced by a high-fat diet.
- Source :
-
Food & function [Food Funct] 2017 Jul 19; Vol. 8 (7), pp. 2455-2464. - Publication Year :
- 2017
-
Abstract
- It has been demonstrated that mangiferin can ameliorate hypertriglyceridemia by modulating the expression levels of genes involved in lipid metabolism in animal experiments, but its effects on the serum metabolic fingerprinting of hyperlipidemia animal models have not been reported. Thus, a NMR-based metabolomics approach was conducted to explore the effects of mangiferin on hyperlipidemia hamsters and to gain a better understanding of the involved metabolic pathways. Hamsters fed with a high-fat diet were orally administered with mangiferin 150 mg per kg BW once a day for 8 weeks. Serum samples were analysed by <superscript>1</superscript> H NMR, and multivariate statistical analysis was applied to the data to identify potential biomarkers. In total, 20 discriminating metabolites were identified. It turned out that mangiferin administration can partly reverse the metabolism disorders induced by a high-fat diet and exerted a good anti-hypertriglyceridemia effect. Mangiferin ameliorated hyperlipidemia by intervening in some major metabolic pathways, involving glycolysis, the TCA cycle, synthesis of ketone bodies, and BCAAs as well as choline and lipid metabolism. These findings provided new essential information on the effects of mangiferin and demonstrated the great potential of this nutrimetabolomics approach.
- Subjects :
- Animals
Biomarkers blood
Biomarkers chemistry
Cricetinae
Humans
Hyperlipidemias metabolism
Lipid Metabolism drug effects
Liver chemistry
Liver metabolism
Male
Mesocricetus
Diet, High-Fat adverse effects
Hyperlipidemias drug therapy
Metabolomics methods
Proton Magnetic Resonance Spectroscopy methods
Xanthones administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 28617510
- Full Text :
- https://doi.org/10.1039/c7fo00081b