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Fatigue evaluation in fingolimod treated patients: An observational study.

Authors :: Masingue M
Debs R
Maillart E
Delvaux V
Lubetzki C
Vidal JS
Papeix C
Source :: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2017 May; Vol. 14, pp. 8-11. Date of Electronic Publication: 2017 Mar 14.
Publication Year :: 2017
Abstract: Background: Fatigue is one of the most disabling symptoms in Multiple Sclerosis (MS) patients and is associated with a low quality of life. Fingolimod (Fg), a sphingosine 1-phosphate receptor modulator, is the first oral MS disease modifying treatment. Little is known about its effect on fatigue. To assess the impact of Fg on fatigue within the first 6 months of treatment in MS patients, we conducted a prospective, open label study, in real life setting.<br />Methods: Change of Modified Fatigue Impact Scale (MFIS) between Fg treatment start and at 6 months was used as a first outcome. Secondary outcomes were changes of MFIS subscales, Fatigue severity scale (FSS) and Visual Analogic Scale of Fatigue (VAS-F) scores, RESULTS: 54 completed the study at M6. No significant change was noted in global MFIS (and neither in sub analysis of MFIS), FSS or VAS-F at M6. Patients with high level of fatigue (MFIS or ≥38) had a higher EDSS score than patients with lower level of fatigue (MFIS <38), (mean 3.3, [SD 1.6] versus 1.6 [SD1.1], p=0.0002) but showed no significant difference in MFIS evolution at M6. There was no significant statistical difference in fatigue parameters evolution at M6 within patients Nz+ or Nz-.<br />Conclusion: There is no significant impact of Fg on fatigue after 6 months of treatment.<br /> (Copyright © 2017. Published by Elsevier B.V.)