Air pollution and genomic instability: The role of particulate matter in lung carcinogenesis.

Authors :: Santibáñez-Andrade M
Quezada-Maldonado EM
Osornio-Vargas Á
Sánchez-Pérez Y
García-Cuellar CM
Source :: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2017 Oct; Vol. 229, pp. 412-422. Date of Electronic Publication: 2017 Jun 13.
Publication Year :: 2017
Abstract: In this review, we summarize and discuss the evidence regarding the interaction between air pollution, especially particulate matter (PM), and genomic instability. PM has been widely studied in the context of several diseases, and its role in lung carcinogenesis gained relevance due to an increase in cancer cases for which smoking does not seem to represent the main risk factor. According to epidemiological and toxicological evidence, PM acts as a carcinogenic factor in humans, inducing high rates of genomic alterations. Here, we discuss not only how PM is capable of inducing genomic instability during the carcinogenic process but also how our genetic background influences the response to the sources of damage.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Subjects :: Carcinogens
Genomic Instability
Humans
Lung drug effects
Neoplasms
Risk Factors
Smoking
Air Pollutants toxicity
Air Pollution statistics & numerical data
Carcinogenesis
Environmental Exposure statistics & numerical data
Lung Neoplasms epidemiology
Particulate Matter toxicity

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