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Temperature-corrected post-mortem 1.5 T MRI quantification of non-pathologic upper abdominal organs.

Authors :
Schwendener N
Jackowski C
Schuster F
Persson A
Warntjes MJ
Zech W-
Source :
International journal of legal medicine [Int J Legal Med] 2017 Sep; Vol. 131 (5), pp. 1369-1376. Date of Electronic Publication: 2017 Jun 17.
Publication Year :
2017

Abstract

Objectives: The present study aimed to evaluate if simultaneous temperature-corrected T1, T2, and proton density (PD) 1.5 T post-mortem MR quantification [quantitative post-mortem magnetic resonance imaging (QPMMRI)] is feasible for characterizing and discerning non-pathologic upper abdominal organs (liver, spleen, pancreas, kidney) with regard to varying body temperatures.<br />Methods: QPMMRI was performed on 80 corpses (25 females, 55 males; mean age 56.2 years, SD 17.2) prior to autopsy. Core body temperature was measured during QPMMRI. Quantitative T1, T2, and PD values were measured in the liver, pancreas, spleen, and left kidney and temperature corrected to 37 °C. Histologic examinations were conducted on each measured organ to determine non-pathologic organs. Quantitative T1, T2, and PD values of non-pathologic organs were ANOVA tested against values of other non-pathologic organ types.<br />Results: Based on temperature-corrected quantitative T1, T2, and PD values, ANOVA testing verified significant differences between the non-pathologic liver, spleen, pancreas, and left kidneys.<br />Conclusions: Temperature-corrected 1.5 T QPMMRI based on T1, T2, and PD values may be feasible for characterization and differentiation of the non-pathologic liver, spleen, pancreas, and kidney. The results may provide a base for future specific pathology diagnosis of upper abdominal organs in post-mortem imaging.

Details

Language :
English
ISSN :
1437-1596
Volume :
131
Issue :
5
Database :
MEDLINE
Journal :
International journal of legal medicine
Publication Type :
Academic Journal
Accession number :
28624986
Full Text :
https://doi.org/10.1007/s00414-017-1622-6