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Chronic Herpetic Retinitis: Clinical Features and Long-Term Outcomes.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2018; Vol. 26 (1), pp. 94-103. Date of Electronic Publication: 2017 Jun 19. - Publication Year :
- 2018
-
Abstract
- Introduction: Chronic uveitis treated with immunosuppressive agents may have unfavorable outcomes due to delays in diagnosis. The aim of this study was to review initial data from clinical and ocular assessments and patient outcomes following specific treatments for atypical herpes virus ocular infections.<br />Methods: The records of four consecutive patients with recurrent uveitis for at least five years treated in our department between 2001 and 2016 were retrospectively reviewed. They had atrophic retinal lesions resulting in an unfavorable outcome with lesion progression and vision loss under immunosuppressive treatment. Varicella zoster virus (1 case) and herpes simplex virus type 2 (3 cases) were detected in ocular samples.<br />Results: Uveitis was granulomatous and bilateral (3 cases) or unilateral (1 case). Immunosuppressive treatments worsened the clinical situation whereas antiherpetic treatments improved the control of intraocular inflammation.<br />Conclusion: This description should be added to the broad repertoire of clinical polymorphisms associated with herpes virus infections. Recognizing these cases should be useful due to their sensitivity to antiherpetic treatments.
- Subjects :
- Adult
Antibodies, Viral blood
Antiviral Agents therapeutic use
Aqueous Humor virology
Chronic Disease
DNA, Viral genetics
Eye Infections, Viral drug therapy
Eye Infections, Viral virology
Female
Follow-Up Studies
Herpes Simplex drug therapy
Herpes Simplex virology
Herpes Zoster Ophthalmicus drug therapy
Herpes Zoster Ophthalmicus virology
Herpesvirus 2, Human genetics
Herpesvirus 2, Human immunology
Herpesvirus 3, Human genetics
Herpesvirus 3, Human immunology
Humans
Male
Middle Aged
Polymerase Chain Reaction
Retinitis drug therapy
Retinitis virology
Retrospective Studies
Treatment Outcome
Eye Infections, Viral diagnosis
Herpes Simplex diagnosis
Herpes Zoster Ophthalmicus diagnosis
Herpesvirus 2, Human isolation & purification
Herpesvirus 3, Human isolation & purification
Retinitis diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 28628343
- Full Text :
- https://doi.org/10.1080/09273948.2017.1327079