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Exceptionally High Payload of the IR780 Iodide on Folic Acid-Functionalized Graphene Quantum Dots for Targeted Photothermal Therapy.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2017 Jul 12; Vol. 9 (27), pp. 22332-22341. Date of Electronic Publication: 2017 Jun 28. - Publication Year :
- 2017
-
Abstract
- The IR780 iodide (IR780) is recognized as an effective theranostic agent for simultaneous near-infrared fluorescence imaging and photothermal therapy (PTT). However, the rigid chloro-cyclohexenyl ring makes IR780 insoluble in almost all pharmaceutically acceptable solvents, which inevitably limits its clinical application. We report folic acid (FA)-functionalized graphene quantum dots (GQDs-FA) containing a large and intact sp <superscript>2</superscript> domain with carboxyl groups around the edge. Such GQDs-FA possess exceptionally high loading capacity for IR780 via strong π-π stacking interactions, and the water solubility of IR780 is improved by over 2400-fold after loading onto GQDs-FA (IR780/GQDs-FA). IR780/GQDs-FA with an improved photostability, an enhanced tumor-targeting ability, and a high photothermal conversion efficiency of 87.9% were capable of producing sufficient hyperthermia to effectively kill cancer cells and completely eradicate tumors upon 808 nm laser irradiation. The present IR780/GQDs-FA may open up great opportunities for the effective PTT to treat cancer.
- Subjects :
- Folic Acid
Graphite
Indoles
Iodides
Quantum Dots
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 9
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 28643511
- Full Text :
- https://doi.org/10.1021/acsami.7b07267