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Coronary microvascular dysfunction in diabetes mellitus.
- Source :
-
The Journal of international medical research [J Int Med Res] 2017 Dec; Vol. 45 (6), pp. 1901-1929. Date of Electronic Publication: 2017 Jan 12. - Publication Year :
- 2017
-
Abstract
- The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives.
Details
- Language :
- English
- ISSN :
- 1473-2300
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of international medical research
- Publication Type :
- Academic Journal
- Accession number :
- 28643578
- Full Text :
- https://doi.org/10.1177/0300060516675504