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Efficacy of Histatin5 in a murine model of vulvovaginal candidiasis caused by Candida albicans.
- Source :
-
Pathogens and disease [Pathog Dis] 2017 Aug 31; Vol. 75 (6). - Publication Year :
- 2017
-
Abstract
- Histatin5 (Hst-5) is a member of the histatin family of antimicrobial peptides secreted by human parotid and submandibular glands. With the natural antibacterial activity, it plays an important role in the first-line barrier of oral cave against pathogens, especially for the fungal intrusion. In this study, we explored the utility of Hst-5 in the treatment of vulvovaginal candidiasis, a common condition of women of the childbearing age. We used a synthesized Hst-5 over five consecutive days as the topical treatment in a murine model of vulvovaginal candidiasis. According to the fungal colony counts, fungal burden in the vagina lavage dropped remarkably after treatment with Hst-5. Furthermore, cytological analysis of the lavage fluid indicated that the number of cast-off cells including cornified epithelial cells and inflammatory cells also decreased; histological evaluation of the vagina tissue revealed less fungi adhering to the vaginal wall in treated animals than in controls. Combined, these results suggested for the first time the potential utility of Hst-5 as a topical treatment for vulvovaginal candidiasis, uncovering the possibility of exploiting the natural antibiotic peptides in other aspects.<br /> (© FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Administration, Intravaginal
Amino Acid Sequence
Animals
Antifungal Agents chemical synthesis
Candida albicans growth & development
Candida albicans pathogenicity
Candidiasis, Vulvovaginal microbiology
Candidiasis, Vulvovaginal pathology
Colony Count, Microbial
Disease Models, Animal
Dose-Response Relationship, Drug
Epithelial Cells drug effects
Epithelial Cells microbiology
Female
Histatins chemical synthesis
Humans
Mice
Mice, Inbred BALB C
Papanicolaou Test
Vagina microbiology
Vagina pathology
Antifungal Agents pharmacology
Candida albicans drug effects
Candidiasis, Vulvovaginal drug therapy
Histatins pharmacology
Vagina drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2049-632X
- Volume :
- 75
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pathogens and disease
- Publication Type :
- Academic Journal
- Accession number :
- 28645176
- Full Text :
- https://doi.org/10.1093/femspd/ftx072