The use of fructosamine in cystic fibrosis-related diabetes (CFRD) screening.

Objective: To determine whether serum fructosamine correlates with glycemic control and clinical outcomes in patients being screened for cystic fibrosis-related diabetes (CFRD).
Methods: Fructosamine and percent predicted forced expiratory volume in 1s (FEV ₁ ) were measured in patients undergoing a 2h oral glucose tolerance test (OGTT) for CFRD screening. Fractional serum fructosamine (FSF) was calculated as fructosamine/total protein.
Results: FSF exhibited a positive correlation with 2h OGTT results (r ² =0.3201, p=0.009), and ROC curve analysis suggested that FSF can identify patients with an abnormal OGTT (AUC=0.840, p=0.0002). FSF also exhibited a negative correlation with FEV ₁ (r ² =0.3732, p=0.035). Patients with FSF≥3.70μmol/g had significantly lower FEV ₁ (median 47%) compared to those with FSF<3.70μmol/g (median 90%; p=0.015).
Conclusions: FSF correlated with both OGTT results and FEV ₁ , and reliably identified patients with abnormal OGTT results. This simple blood test shows potential as an effective tool in CFRD screening.
(Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)