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Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly: A prospective, randomized, controlled trial.
- Source :
-
Medicine [Medicine (Baltimore)] 2017 Jun; Vol. 96 (26), pp. e7375. - Publication Year :
- 2017
-
Abstract
- Electro-acupuncture is a burgeoning treatment using the needle inserting into the body acupoints and the low-frequency pulse current being electrified by an electric acupuncture machine. This study was designed to evaluate the effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly.Ninety patients scheduled spine surgery were randomly assigned into 2 groups using a random number table: control group (group C) and electro-acupuncture group (group EA). In group EA, electro-acupuncture was applied on Baihui, Dazhui, and Zusanli acupoints 30 minutes before anesthesia. At 0 minute before treatment of electro-acupuncture, 1 hour after skin incision and surgery completed (T1-3), blood samples were taken for detection of interleukin (IL)-6, IL-10, and S100β by enzyme-linked immunosorbent assay. The total dose of remifentanil and propofol during surgery were recorded. Mini-Mental State Examination was applied to evaluate the cognitive function of patients at 1 day before surgery and 7th and 30th day after surgery.The results showed that compared with group C, score of MMSE increased after surgery, the serum concentration of IL-6, IL-10, and S100β decreased at 1 hour after skin incision, and surgery completed in group EA. Moreover, the total dose of remifentanil and propofol reduced during surgery in group EA.The present study suggests that preconditioning of electro-acupuncture could improve the postoperative cognitive function, and the reduction of inflammatory reaction and brain injury may be involved in the mechanism.
- Subjects :
- Aged
Anesthetics, Intravenous therapeutic use
Biomarkers blood
Cognitive Dysfunction blood
Female
Humans
Interleukin-10 blood
Interleukin-6 blood
Male
Mental Status Schedule
Operative Time
Orthopedic Procedures
Piperidines therapeutic use
Postoperative Complications blood
Postoperative Complications psychology
Propofol therapeutic use
Remifentanil
S100 Calcium Binding Protein beta Subunit blood
Treatment Outcome
Cognitive Dysfunction etiology
Cognitive Dysfunction prevention & control
Electroacupuncture
Postoperative Complications prevention & control
Preoperative Care
Spine surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 96
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28658163
- Full Text :
- https://doi.org/10.1097/MD.0000000000007375