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Effect of dietary consumption as a modifier on the association between FTO gene variants and excess body weight in children from an admixed population in Brazil: the Social Changes, Asthma and Allergy in Latin America (SCAALA) cohort study.
- Source :
-
The British journal of nutrition [Br J Nutr] 2017 Jun; Vol. 117 (11), pp. 1503-1510. Date of Electronic Publication: 2017 Jun 29. - Publication Year :
- 2017
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Abstract
- Previous studies have shown associations of variants of the FTO gene with body weight, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the north-eastern Brazilian population. This study evaluated the association between SNP in the FTO gene and excess weight in Salvador, Bahia, Brazil. In addition, the effect of diet as a modifier on this association was also investigated. This cross-sectional study included 1191 participants aged 4-11 years, who were genotyped for 400 variants of the FTO gene. Direct anthropometric measures were made and dietary data were obtained by 24-h food recall. Multivariate logistic regression analyses were used to assess the associations of interest. Overall, 11·2 % of the individuals included in the study were overweight/obese. Interactions were identified between the percentage energy intake from proteins and obesity risk linked to the rs62048379 SNP (P interaction=0·01) and also between fat intake (PUFA:SFA ratio) and obesity risk linked to the rs62048379 SNP (P interaction=0·01). The T allele for the variant rs62048379 was positively associated with overweight/obesity in individuals whose percentage energy intake from protein was above the median (OR 2·00; 95 % CI 1·05, 3·82). The rs62048379 SNP was also associated with overweight/obesity in individuals whose PUFA:SFA ratio was below the median (OR 1·63; 95 % CI 1·05, 2·55). The association between FTO gene variants and excess body weight can be modulated by dietary characteristics, particularly by fatty acid distribution and dietary protein intake in children.
- Subjects :
- Alleles
Brazil
Child
Child, Preschool
Cross-Sectional Studies
Diet Surveys
Energy Intake
Feeding Behavior
Female
Humans
Logistic Models
Male
Overweight genetics
Pediatric Obesity genetics
Racial Groups
Alpha-Ketoglutarate-Dependent Dioxygenase FTO genetics
Body Weight
Diet
Gene-Environment Interaction
Genotype
Obesity genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 117
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 28659218
- Full Text :
- https://doi.org/10.1017/S0007114517001386