Three New Abietane-Type Diterpenoids from Plectranthus africanus and Their Antibacterial Activities.

Three new abietane-type diterpenoids, plectranthroyleanones A - C (1:  - 3: ), together with five known compounds (4:  - 8: ) were isolated from the methanol extract of the whole plant of Plectranthus africanus using column chromatography techniques. The structures of the new compounds were elucidated using a combination of 1D and 2D NMR and HRESIMS analyses. Compound 1: exhibited weak activities with minimal inhibitory concentration values of 75 µg/mL against gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus , and 150 µg/mL against two gram-negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumoniae , respectively, while 2: and 3: had moderate antibacterial activity against K. pneumoniae with a minimal inhibitory concentration value of 37.5 µg/mL.
Competing Interests: Conflict of Interest: The authors declare no conflict of interest.
(Georg Thieme Verlag KG Stuttgart · New York.)