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The Blood Oxygenation T 2 * Values of Resectable Esophageal Squamous Cell Carcinomas as Measured by 3T Magnetic Resonance Imaging: Association with Tumor Stage.
- Source :
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Korean journal of radiology [Korean J Radiol] 2017 Jul-Aug; Vol. 18 (4), pp. 674-681. Date of Electronic Publication: 2017 May 19. - Publication Year :
- 2017
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Abstract
- Objective: To explore the association between the blood oxygenation T <subscript>2</subscript> <superscript>*</superscript> values of resectable esophageal squamous cell carcinomas (ESCCs) and tumor stages.<br />Materials and Methods: This study included 48 ESCC patients and 20 healthy participants who had undergone esophageal T <subscript>2</subscript> <superscript>*</superscript> -weighted imaging to obtain T <subscript>2</subscript> <superscript>*</superscript> values of the tumors and normal esophagi. ESCC patients underwent surgical resections less than one week after imaging. Statistical analyses were performed to identify the association between T <subscript>2</subscript> <superscript>*</superscript> values of ESCCs and tumor stages.<br />Results: One-way ANOVA and Student-Newman-Keuls tests revealed that the T <subscript>2</subscript> <superscript>*</superscript> value could differentiate stage T1 ESCCs (17.7 ± 3.3 ms) from stage T2 and T3 tumors (24.6 ± 2.7 ms and 27.8 ± 5.6 ms, respectively; all p <subscript>s</subscript> < 0.001). Receiver operating curve (ROC) analysis showed the suitable cutoff T <subscript>2</subscript> <superscript>*</superscript> value of 21.3 ms for either differentiation. The former statistical tests demonstrated that the T <subscript>2</subscript> <superscript>*</superscript> value could not differentiate between stages T2 and T3 (24.6 ± 2.7 ms vs. 27.8 ± 5.6 ms, respectively, p > 0.05) or between N stages (N1 vs. N2 vs. N3: 24.7 ± 6.9 ms vs. 25.4 ± 4.5 ms vs. 26.8 ± 3.9 ms, respectively; all p <subscript>s</subscript> > 0.05). The former tests illustrated that the T <subscript>2</subscript> <superscript>*</superscript> value could differentiate anatomic stages I and II (18.8 ± 4.8 ms and 26.9 ± 5.9 ms, respectively) or stages I and III (27.3 ± 3.6 ms). ROC analysis depicted the same cutoff T <subscript>2</subscript> <superscript>*</superscript> value of 21.3 ms for either differentiation. In addition, the Student's t test revealed that the T <subscript>2</subscript> <superscript>*</superscript> value could determine grouped T stages (T0 vs. T1-3: 17.0 ± 2.9 ms vs. 25.2 ± 6.2 ms; T0-1 vs. T2-3: 17.3 ± 3.0 ms vs. 27.1 ± 5.3 ms; and T0-2 vs. T3: 18.8 ± 4.2 ms vs. 27.8 ± 5.6 ms, all p <subscript>s</subscript> < 0.001). ROC analysis indicated that the T <subscript>2</subscript> <superscript>*</superscript> value could detect ESCCs (cutoff, 20 ms), and discriminate between stages T0-1 and T2-3 (cutoff, 21.3 ms) and between T0-2 and T3 (cutoff, 20.4 ms).<br />Conclusion: The T <subscript>2</subscript> <superscript>*</superscript> value can be an additional quantitative indicator for detecting ESCC except for stage T1 cancer, and can preoperatively discriminate between some T stages and between anatomic stages of this tumor.
- Subjects :
- Aged
Area Under Curve
Carcinoma, Squamous Cell pathology
Case-Control Studies
Esophageal Neoplasms pathology
Esophageal Squamous Cell Carcinoma
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Neoplasm Staging
ROC Curve
Carcinoma, Squamous Cell diagnostic imaging
Esophageal Neoplasms diagnostic imaging
Magnetic Resonance Imaging
Oxygen blood
Subjects
Details
- Language :
- English
- ISSN :
- 2005-8330
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Korean journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 28670162
- Full Text :
- https://doi.org/10.3348/kjr.2017.18.4.674