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Prospective clinical trials to investigate clinical and molecular biomarkers.
- Source :
-
Epilepsia [Epilepsia] 2017 Jul; Vol. 58 Suppl 3, pp. 20-26. - Publication Year :
- 2017
-
Abstract
- Among clinical studies, randomized studies as well as well-designed observational studies are providing the highest quality data. In addition, these studies represent a good opportunity to examine biomarkers of ictogenesis and epileptogenesis. To date, no validated molecular or cellular biomarker exists for any aspect of epilepsy. We provide an overview of the inflammatory biomarkers under investigation in prospective clinical studies in epilepsy: proinflammatory cytokines in prolonged febrile seizure; High Mobility Group Box 1 (HMGB1) as a prognosis biomarker in epilepsy and the interaction between inflammation and metabolism, in particular, iron metabolism, in epilepsy. The designs of the European Union EPISTOP project following prospectively patients with tuberous sclerosis from birth to the start of the epilepsy and of the Standard and New Antiepileptic Drugs-II study illustrate how such studies can be used to find new inflammatory biomarkers of ictogenesis and epileptogenesis. If we want to bridge the current gap between having numerous biomarker candidates from preclinical studies and their selective use in clinical practice, we need to explore multiple biologic systems, not just including inflammation. In addition, it is crucial that those involved in the design and support of relevant clinical studies recognize this gap and act accordingly, and in the interests of improving the diagnosis and prognosis for epilepsy.<br /> (Wiley Periodicals, Inc. © 2017 International League Against Epilepsy.)
- Subjects :
- Animals
Disease Models, Animal
HMGB1 Protein analysis
Humans
Inflammation Mediators analysis
Observational Studies as Topic
Prognosis
Prospective Studies
Randomized Controlled Trials as Topic
Biomarkers analysis
Epilepsy diagnosis
Epilepsy physiopathology
Neurogenic Inflammation diagnosis
Neurogenic Inflammation physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1528-1167
- Volume :
- 58 Suppl 3
- Database :
- MEDLINE
- Journal :
- Epilepsia
- Publication Type :
- Academic Journal
- Accession number :
- 28675556
- Full Text :
- https://doi.org/10.1111/epi.13782