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Intrathecal immunoglobulin synthesis in patients with symptomatic epilepsy and epilepsy of unknown etiology ('cryptogenic').
- Source :
-
European journal of neurology [Eur J Neurol] 2017 Sep; Vol. 24 (9), pp. 1188-1190. Date of Electronic Publication: 2017 Jul 05. - Publication Year :
- 2017
-
Abstract
- Background and Purpose: To compare the frequency of intrathecal immunoglobulin (Ig) synthesis in patients with symptomatic epilepsy and epilepsy of unknown etiology ('cryptogenic').<br />Methods: Patients with epileptic (n = 301) and non-epileptic (n = 10) seizures were retrospectively screened for autochthonous intrathecal Ig synthesis and oligoclonal bands (OCBs) in the cerebrospinal fluid.<br />Results: Intrathecal IgG/OCBs were detected in 8% of patients with epilepsies of unknown etiology, 5% of patients with first seizures of unknown cause and 0-4% of patients with epilepsy due to brain tumors, cerebrovascular disease or other etiologies. Intrathecal IgG/OCBs were not seen in patients with psychogenic seizures. Identical OCBs in serum and cerebrospinal fluid were more common in all patient groups (10-40% depending on underlying etiology).<br />Conclusions: Intrathecal IgG synthesis/OCBs were observed slightly more frequently in patients with 'cryptogenic' epilepsy and with first seizures of unknown etiology than in other patient groups. However, this remained an infrequent finding and thus we could not confirm humoral immunity as a leading disease mechanism in patients with epilepsy in general or with unknown etiology in particular.<br /> (© 2017 EAN.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Epilepsy etiology
Epilepsy immunology
Female
Humans
Immunoglobulin A biosynthesis
Immunoglobulin A cerebrospinal fluid
Immunoglobulin G biosynthesis
Immunoglobulin G cerebrospinal fluid
Immunoglobulin M biosynthesis
Immunoglobulin M cerebrospinal fluid
Immunoglobulins biosynthesis
Male
Middle Aged
Oligoclonal Bands cerebrospinal fluid
Oligoclonal Bands immunology
Retrospective Studies
Seizures cerebrospinal fluid
Seizures immunology
Seizures metabolism
Young Adult
Epilepsy cerebrospinal fluid
Immunoglobulins cerebrospinal fluid
Spinal Cord metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1468-1331
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28677890
- Full Text :
- https://doi.org/10.1111/ene.13348