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Restraining Pathogenicity in Candida albicans by Taxifolin as an Inhibitor of Ras1-pka Pathway.
- Source :
-
Mycopathologia [Mycopathologia] 2017 Dec; Vol. 182 (11-12), pp. 953-965. Date of Electronic Publication: 2017 Jul 05. - Publication Year :
- 2017
-
Abstract
- Candida albicans is one of the most virulent and opportunistic fungal strains. In the present scenario, majority metabolic imbalances and unsuccessful treatments of some severe diseases including cancer, diabetes, HIV, psoriasis are because of invasive Candida emergence. Being a beneficial integral part of human biome, its elimination is not possible. The major pathogenicity characteristics in Candida involve hyphal growth, biofilm formation, HSP90 down regulation and genetic modifications. Ras1-pka pathway initiated by HSP90 down regulation is important for hyphal growth and has been focused in the present study. The principle transcriptional factors that induce hyphal growth causing invasiveness and virulence through this pathway have been identified as Tec1 and Rfg1. In the present study, taxifolin, a naturally occurring polyphenol, has been identified as inhibitor for both the transcriptional factors in parallel.
- Subjects :
- Binding Sites
Candida albicans drug effects
Candidiasis microbiology
Catalytic Domain
HSP90 Heat-Shock Proteins biosynthesis
Humans
Hyphae growth & development
Molecular Docking Simulation
Molecular Dynamics Simulation
Quercetin pharmacology
ras Proteins antagonists & inhibitors
Antifungal Agents pharmacology
Candida albicans pathogenicity
Candidiasis drug therapy
DNA-Binding Proteins antagonists & inhibitors
Fungal Proteins antagonists & inhibitors
Quercetin analogs & derivatives
Repressor Proteins antagonists & inhibitors
Transcription Factors antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0832
- Volume :
- 182
- Issue :
- 11-12
- Database :
- MEDLINE
- Journal :
- Mycopathologia
- Publication Type :
- Academic Journal
- Accession number :
- 28681317
- Full Text :
- https://doi.org/10.1007/s11046-017-0170-4