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Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways.
- Source :
-
Genomics [Genomics] 2017 Oct; Vol. 109 (5-6), pp. 408-418. Date of Electronic Publication: 2017 Jul 04. - Publication Year :
- 2017
-
Abstract
- ANGPTL8 (Angiopoietin-like protein 8) is a newly identified hormone emerging as a novel drug target for treatment of diabetes mellitus and dyslipidemia due to its unique metabolic nature. With increasing number of studies targeting the regulation of ANGPTL8, integration of their findings becomes indispensable. This study has been conducted with the aim to collect, analyze, integrate and visualize the available knowledge in the literature about ANGPTL8 and its regulation. We utilized this knowledge to construct a regulatory pathway of ANGPTL8 which is available at WikiPathways, an open source pathways database. It allows us to visualize ANGPTL8's regulation with respect to other genes/proteins in different pathways helping us to understand the complex interplay of novel hormones/genes/proteins in metabolic disorders. To the best of our knowledge, this is the first attempt to present an integrated pathway view of ANGPTL8's regulation and its associated pathways and is important resource for future omics-based studies.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Angiopoietin-Like Protein 8
Animals
Cell Proliferation
Cells, Cultured
Databases, Genetic
Gene Expression Regulation
Gene Regulatory Networks
Humans
Insulin-Secreting Cells cytology
Insulin-Secreting Cells metabolism
Signal Transduction
Web Browser
Angiopoietin-like Proteins genetics
Angiopoietin-like Proteins metabolism
Glucose metabolism
Lipid Metabolism
Peptide Hormones genetics
Peptide Hormones metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8646
- Volume :
- 109
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 28684091
- Full Text :
- https://doi.org/10.1016/j.ygeno.2017.06.006