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European LeukemiaNet study on the reproducibility of bone marrow features in masked polycythemia vera and differentiation from essential thrombocythemia.
- Source :
-
American journal of hematology [Am J Hematol] 2017 Oct; Vol. 92 (10), pp. 1062-1067. Date of Electronic Publication: 2017 Jul 29. - Publication Year :
- 2017
-
Abstract
- The purpose of the study was to assess consensus and interobserver agreement among an international panel of six hematopathologists regarding characterization and reproducibility of bone marrow (BM) histologic features used to diagnose early stage myeloproliferative neoplasms, in particular differentiation of so-called masked/prodromal polycythemia vera (mPV) from JAK2-mutated essential thrombocythemia (ET). The six members of the hematopathology panel evaluated 98 BM specimens independently and in a blinded fashion without knowledge of clinical data. The specimens included 48 cases of mPV according to the originally published hemoglobin threshold values for this entity (male: 16.0-18.4 g/dL, female: 15.0-16.4 g/dL), 31 cases with overt PV according to the updated 2016 WHO criteria, and 19 control cases. The latter group included cases of JAK2-mutated ET, primary myelofibrosis, myelodysplastic syndrome, and various reactive conditions. Inter-rater agreement between the panelists was very high (overall agreement 92.6%, kappa 0.812), particularly with respect to separating mPV from ET. Virtually all cases of mPV were correctly classified as PV according to their BM morphology. In conclusion, a central blinded review of histology slides by six hematopathologists demonstrated that highly reproducible specific histological pattern characterize PV and confirmed the notion that there are no significant differences between mPV and overt PV in relation to BM morphology.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Diagnosis, Differential
Europe
Female
Hemoglobins analysis
Humans
Janus Kinase 2 genetics
Male
Mutation
Polycythemia Vera blood
Polycythemia Vera genetics
Reproducibility of Results
Thrombocythemia, Essential blood
Thrombocythemia, Essential genetics
World Health Organization
Bone Marrow pathology
Polycythemia Vera pathology
Thrombocythemia, Essential pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-8652
- Volume :
- 92
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- American journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 28685840
- Full Text :
- https://doi.org/10.1002/ajh.24837