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Progress in Our Understanding of Wzx Flippase for Translocation of Bacterial Membrane Lipid-Linked Oligosaccharide.
- Source :
-
Journal of bacteriology [J Bacteriol] 2017 Dec 05; Vol. 200 (1). Date of Electronic Publication: 2017 Dec 05 (Print Publication: 2018). - Publication Year :
- 2017
-
Abstract
- Translocation of lipid-linked oligosaccharides is a common theme across prokaryotes and eukaryotes. For bacteria, such activity is used in cell wall construction, polysaccharide synthesis, and the relatively recently discovered protein glycosylation. To the best of our knowledge, the Gram-negative inner membrane flippase Wzx was the first protein identified as being involved in oligosaccharide translocation, and yet we still have only a limited understanding of this protein after 3 decades of research. At present, Wzx is known to be a multitransmembrane protein with enormous sequence diversity that flips oligosaccharide substrates with varied degrees of preference. In this review, we provide an overview of the major findings for this protein, with a particular focus on substrate preference.<br /> (Copyright © 2017 American Society for Microbiology.)
- Subjects :
- Cell Membrane chemistry
Cell Membrane metabolism
Escherichia coli Proteins chemistry
Escherichia coli Proteins genetics
Glycomics
Membrane Lipids chemistry
Membrane Transport Proteins chemistry
Membrane Transport Proteins genetics
O Antigens metabolism
Oligosaccharides metabolism
Escherichia coli Proteins metabolism
Gram-Negative Bacteria metabolism
Lipopolysaccharides metabolism
Membrane Lipids metabolism
Membrane Transport Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5530
- Volume :
- 200
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- 28696276
- Full Text :
- https://doi.org/10.1128/JB.00154-17