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Physicochemical regulation of TGF and VEGF delivery from mesoporous calcium phosphate bone substitutes.
- Source :
-
Nanomedicine (London, England) [Nanomedicine (Lond)] 2017 Aug; Vol. 12 (15), pp. 1835-1850. Date of Electronic Publication: 2017 Jul 13. - Publication Year :
- 2017
-
Abstract
- Aim: Determination of the physicochemical parameters governing growth factors (GFs) adsorption and release from mesoporous calcium phosphate ceramics.<br />Materials & Methods: Six mesoporous calcium phosphate ceramics prepared by soft and hard templating were loaded with two different physiological concentrations of TGF-β1 or VEGF <subscript>165</subscript> and their in vitro kinetics of adsorption/release were studied.<br />Results: This low GF loading promotes adsorption on the highest binding sites. The usually encountered detrimental burst release is thus considerably reduced for samples prepared by hard-templating method.<br />Conclusion: Our findings highlight that the strong affinity of GFs with the ceramic surfaces, demonstrated by a slow GFs release, is enhanced by the large surface area, confinement into mesopores of ceramics and high difference of surface charge between ceramic surfaces and GFs.
- Subjects :
- Adsorption
Biocompatible Materials chemical synthesis
Bone Regeneration drug effects
Bone Substitutes metabolism
Ceramics chemical synthesis
Drug Liberation
Humans
Porosity
Surface Properties
Transforming Growth Factor beta1 pharmacology
Vascular Endothelial Growth Factor A pharmacology
Bone Substitutes chemistry
Calcium Phosphates chemical synthesis
Drug Carriers chemical synthesis
Transforming Growth Factor beta1 chemistry
Vascular Endothelial Growth Factor A chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1748-6963
- Volume :
- 12
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Nanomedicine (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 28703639
- Full Text :
- https://doi.org/10.2217/nnm-2017-0158