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Cobalt Catalysis for Enantioselective Cyclobutanone Construction.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2017 Aug 02; Vol. 139 (30), pp. 10208-10211. Date of Electronic Publication: 2017 Jul 13. - Publication Year :
- 2017
-
Abstract
- Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol % catalyst loading and as low as 50 °C).
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 139
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 28704053
- Full Text :
- https://doi.org/10.1021/jacs.7b05327